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Intracellular deoxygenated Hb S polymers lead to sickling

Under deoxygenated (or partially deoxygenated) conditions, deoxyHb S polymers form parallel-oriented fiber bundles[55], or "fascicles" [62]. The fascicles form because deoxyHb S has a very low solubility in intact RBCs, and insoluble deoxyHb S  either initiates or facilitates a change in the cytoskeleton of certain subpopulations of RBCs[55].